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Taking Your Medication
⏲ 2 min 55 sec ✓ 13-Nov-2014
Xeljanz Lawsuit
⏲ 2 minutes 18 seconds 👁 1.3K
Xeljanz Overview
⏲ 49 seconds 👁 1K
Hip Replacement Surgery Recovery Time: हिप रिप्लेसमेंट के बाद जीवन, रिकवरी टाइम |Boldsky
⏲ 2:46 👁 4.7M
Xeljanz (Tofacitinib) - How it Works and Its Indications
⏲ 3 minutes 45 seconds 👁 3.8K
Tofacitinib (Xeljanz): A Practical Review
⏲ 4 minutes 47 seconds 👁 2.5K
Sunderland's pharmacists warn of healthcare 'crisis' with medication shortages due to funding cuts
⏲ 2:54 👁 130K
Discover the Benefits and Side Effects of Xeljanz or tofacitinib (rheumatoid arthritis)
⏲ 9 minutes 1 second 👁 188
Xeljanz
⏲ 10 minutes 34 seconds 👁 4.8K
How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
New drug to help treat inflammatory arthritis listed on the PBS | 7NEWS
⏲ 1 minute 24 seconds 👁 8K
Xeljanz vs Rinvoq: Same Drug Class But Is One Really Better Than The Other?
⏲ 8 minutes 23 seconds 👁 2.2K
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_taking-your-medication.webp "Taking Xeljanz")
_xeljanz-lawsuit.webp "TorHoerman Law")
_xeljanz-overview.webp "RxWikiTV")
_hip-replacement-surgery-recovery-time-124boldsky.webp "Your doctor may discuss hip replacement surgery when non-surgical treatments, such as medication and physical therapy fail to provide adequate relief. Hip replacement surgery can eliminate pain, restore joint function, and enable you to enjoy life again, but there are many essential steps on the road to recovery.Hip Replacement Surgery Recovery Time: Hip Replacement Ke Baad Jeewan, FULL VIDEO... <br/> <br/>#hipreplacementsurgery #hipreplacementsurgeryrecoverytime #hipreplacementsurgeryrecovery #hipreplacementrecoveryweekbyweek #hipreplacementwhattoexpect #hipreplacementsurgeryvideo <br/>~PR.111~ED.120~HT.318~")
_xeljanz-tofacitinib-how-it-works-and-its-indications.webp "medXclusive Learning")
_tofacitinib-xeljanz-a-practical-review.webp "TeachMeMedicine.org")
_sunderland39s-pharmacists-warn-of-healthcare-39crisis39-with-medication-shortages-due-to-funding-cuts.webp "Herdman Chemists pharmacist Ilyas Zaheer discusses the impacts of the current 'funding crisis'.")
_discover-the-benefits-and-side-effects-of-xeljanz-or-tofacitinib-rheumatoid-arthritis.webp "Inevid")
_xeljanz.webp "wellnowdoctor")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_new-drug-to-help-treat-inflammatory-arthritis-listed-on-the-pbs-124-7news.webp "7NEWS Australia")
_xeljanz-vs-rinvoq-same-drug-class-but-is-one-really-better-than-the-other.webp "Curtis Alexander, Pharm.D.")
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